Rapid introduction of oral antivirals for COVID-19: implementation of a test and treat program in four African countries

Introduction: Despite availability of approved oral antivirals like nirmatrelvir/ritonavir to treat COVID-19 in high-income countries since 2021, access to these drugs remains largely unavailable across the African continent.Ghana, Malawi, Rwanda and Zambia, all members of the COVID Treatment QuickStart Consortium, leveraged existing infrastructure

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Dose-response met-RANTES treatment of experimental periodontitis: a narrow edge between the disease severity attenuation and infection control.

Chemokines and chemokine receptors have been implicated in the selective migration of leukocyte subsets to periodontal tissues, which consequently influences the disease outcome.Among these chemoattractants, the chemokines CCL3, CCL4 and CCL5 and its receptors, CCR1 and CCR5, have been associated with increased disease severity in mice and humans.T

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Data assimilation as a learning tool to infer ordinary differential equation representations of dynamical models

Recent progress in machine learning has shown how to forecast and, to some extent, learn the dynamics of a model from its output, resorting in particular to neural networks and deep learning techniques.We will show how the same eeboo coupons goal can be directly achieved using data assimilation techniques without leveraging on machine learning soft

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